Irwan Hanish

Back to Immunotolerance

Practice Questions for Immunotolerance

Answer each question from memory first, aloud or on paper. Then rewatch Immunotolerance to check yourself.

  1. Explain the concept of immunotolerance and its significance in the immune system.
  2. What happens when immune tolerance to self-antigens fails?
  3. Describe the regulatory factors the body uses to influence immune tolerance.
  4. Where are the locations in which the immune system inactivates lymphocytes that display high-affinity receptors for self-antigens?
  5. Compare and contrast central and peripheral tolerance.
  6. Describe the fate of T cells that recognise self-antigens with high affinity in the process of central T cell tolerance.
  7. Outline the three mechanisms of peripheral T cell tolerance. Explain how each mechanism contributes to preventing autoimmune responses.
  8. Discuss the three mechanisms of action of regulatory T cells (Tregs).
  9. Explain the location and processes of central B tolerance.
  10. Describe the four mechanisms of peripheral B cell tolerance.