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- Explain the concept of immunotolerance and its significance in the immune system.
- Discuss what happens in the failure of the immune system to recognise self-antigens.
- Describe the regulatory factors the body uses to influence immune tolerance.
- Where are the locations in which the immune system inactivates lymphocytes that display high-affinity receptors for self-antigens?
- Compare and contrast central and peripheral tolerance.
- Describe the fate of T cells that recognise self-antigens with high affinity in the process of central T cell tolerance.
- Outline the three mechanisms of peripheral T cell tolerance. Explain how each mechanism contributes to preventing autoimmune responses.
- Discuss the three mechanisms of action of regulatory T cells (Tregs).
- Explain the location and processes of central B tolerance.
- Describe the four mechanisms of peripheral B cell tolerance.